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ISSN: 0033-3158 (printed version)
ISSN: 1432-2072 (electronic version)

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Abstract Volume 132 Issue 1 (1997) pp 104-106 

Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors

Michèle Arnone (2), Jeanne Maruani (1), Frédérique Chaperon (3), Marie-Hélène Thiébot (3), M. Poncelet (1), Philippe Soubrié (1), Gérard Le Fur (1)

(1) Sanofi Recherche, 371 Rue du Professeur Blayac, F-34084 
Montpellier, France
(2) Sanofi Recherche, Route d'Espagne, F-31000 Toulouse, France
(3) INSERM U.288, Faculté de Médecine Pitié Salpêtrière, 91 
Boulevard de l'Hôpital, F-75634 Paris, France

Received: 31 January 1997/Final version: 16 March 1997

SR 141716, a selective central CB1 cannabinoid receptor antagonist, markedly and selectively reduces sucrose feeding and drinking as well as neuropeptide Y-induced sucrose drinking in rats. SR 141716 also decreases ethanol consumption in C57BL/6 mice. In contrast, blockade of CB1 receptors only marginally affects regular chow intake or water drinking. The active doses of SR 141716 (0.3-3 mg/kg) are in the range known to antagonize the characteristic effects induced by cannabinoid receptor agonists. These results suggest for the first time that endogenous cannabinoid systems may modulate the appetitive value of sucrose and ethanol, perhaps by affecting the activity of brain reward systems.

Key words Sucrose intake · Ethanol consumption · Cannabinoid receptor · SR 141716 · Rats · Mice Article in PDF-Format

Last change: July 14, 1997 
© Springer Berlin Heidelberg 1997

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