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Major Studies of Drugs and Drug Policy
Canadian Senate Special Committee on Illegal Drugs
Volume I - General Orientation

Chapter 8 - Driving Under the Influence of Cannabis

Epidemiological data

 

According to a number of the witnesses we heard, more than 40% of people whose driving abilities are impaired would drive under the influence of cannabis. Others have said that approximately 12% of accidents causing injury could be attributed to the use of cannabis. What do the studies reveal?

Data on the frequency of driving under the influence of cannabis (whether on its own or together with other substances) are, for obvious reasons, difficult to obtain. First, for drivers involved in an accident, a positive breathalyzer test means most of the time that no other measurements are taken because a blood alcohol level above the legal limit is enough to take legal action. Second, the methods available to detect the presence of THC are intrusive (blood, urine), unlike the breathalyzer, and hence pose specific legal and ethical problems. Other forms of measurements, such as saliva samples, do not, for the time being, allow roadside detection. Lastly, in studies of all drivers, the consent of drivers is required to take a blood or urine sample, thus limiting the possibility of generalizing results. Nevertheless, we will summarize the main points of a number of studies conducted in recent years.

 

Studies not involving accidents

Two types of studies were conducted: surveys of all drivers selected at random from the flow of traffic at various times of the day and week, and studies where it was presumed that the people were driving under the influence during police checks. The following table, drawn from the various data available from INSERM, summarizes these studies.

 Epidemiological studies on youth

In recent years, epidemiological studies on youth in the school environment have asked questions about the frequency of driving under the influence of psychoactive substances, cannabis in particular. In Ontario, the 2002 OSDUS study described in Chapter 6 shows that 19.3% of the students had driven their car one hour or less after having taken cannabis at least once in the past twelve months.[1][19] More interesting is that this compares with 15% who said they had taken their car less than an hour after one or two drinks. In Manitoba, the survey of youths in school reveals that almost 20% see nothing wrong in driving after taking cannabis.[2][20]

Finally, the Cohen and Kaal study on long term consumers had shown that no less than 42% of the respondents in Amsterdam and 74% in San Francisco had driven their car under the influence of cannabis.[3][21]

 

Risk assessment

Given the difficulties of conducting reliable epidemiological studies on driving under the influence of cannabis, a number of authors have analyzed the probability of responsibility and the risk ratio involved in the use of cannabis. These studies distinguish between drivers who are responsible for accidents and those who are not. The former are the subjects and the latter the control group. Comparisons are then made of their intoxication to various substances. Clearly, placing drivers into the two categories of responsible/not responsible may depend on an investigator’s perception of whether or not psychoactive substances are present.

The following table, which is reproduced from the Ramaekers et al. report (2002) for the International Scientific Conference on Cannabis summarizes the results of various studies.[4][22] It should be pointed out that the probability of responsibility for drivers showing traces of cannabis (D9THC and/or D9THC–COOH, whether measured in blood or urine) is compared to the responsibility of drivers involved in an accident not testing positive to any substance (including alcohol). The risk ratio for drivers not testing positive to any substances is 1.0 and is used as a point of comparison to determine the statistical significance of observed change in the risk level of impaired drivers. When the reference value is above the statistical confidence level of 95%, the obvious conclusion is that the drug is 95% associated with an increased risk of responsibility.

 

Level of culpability relative to driving under the influence of cannabis

Authors

Substance

Odds ratio

Confidence interval at 95%

N of drivers culpable / not culpable

 

Terhune & Fell (1982), U.S.

 

 

 

Williams et al. (1985), U.S.

 

 

 

Terhune et al. (1992), U.S.

 

 

 

Drummer (1994), Australia

 

 

 

 

Hunter et al. (1998), Australia

 

 

 

 

 

 

 

 

 

 

 

 

 

Lowenstein & Koziol-McLain (2001), U.S.

 

 

Drummer et al. (2001) & Swann (2000), Australia

 

 

Drug free cases

Alcohol

THC

Alcohol/THC

 

Drug free cases

Alcohol

THC or THC-COOH

Alcohol/THC or THC-COOH

 

Drug free cases

Alcohol

THC

Alcohol/THC

 

Drug free cases

Alcohol

THC-COOH

Alcohol/THC-COOH

 

 

Drug free cases

Alcohol

THC

âØ £ 1.0 ng/ml

âØ 1,1 – 2,0 ng/ml

âØ > 2 ng/ml

 

THC-COOH

âØ 1 – 10 ng/ml

âØ 11 – 20 ng/ml

âØ 21 – 30 ng/ml

âØ > 30 ng/ml

 

Alcohol/THC

 

No substance

Alcohol

THC-COOH

Alcohol/THC-COOH

 

No substance

Alcohol

THC

THC > 5 ng/ml

THC-COOH

Alcohol/THC

 

1.0

5.4*

2.1

-

 

1.0

5.0

0.2

8.6*

 

1.0

7.4*

0.7

8.4*

 

1.0

5.5*

0.7

5.3*

 

1.0

6.8*

 

0.35

0.51

1.74

 

 

0.69

1.04

0.87

1.62

 

11.5*

 

1.0

3.2

1.1

3.5*

 

1.0

5.7*

3.0*

6.4*

0.8

19*

 

 

2.8 – 10.5

0.7 – 6.6

 

 

 

2.1 – 12.2

0.2 – 1.5

3.1 – 26.9

 

 

5.1 – 10.7

0.2 – 1.8

2.1 – 72.1

 

 

3.2 – 9.6

0.4 – 1.5

1.9 – 20.3

 

 

4.3 – 11.1

 

0.3 – 2.1

0.2 – 1.4

0.6 – 5.7

 

 

0.5 – 2.2

0.4 – 2.1

0.6 – 4.8

0.6 – 4.8

 

4.6 – 36.7

 

 

1.1 – 9.4

0.5 – 2.4

1.2 – 11.4

 

 

4.1 – 8.2

1.2 – 7.6

1.3 – 115.7

0 – 1.3

2.6 – 136.1

 

94/179

45/16

9/8

-

 

55/23

120/10

10/9

123/6

 

541/258

587/38

11/8

35/2

 

392/140

261/17

29/14

59/9

 

944/821

173/22

 

2/5

7/12

12/6

 

 

19/24

18/15

12/12

13/7

 

66/6

 

114/126

17/6

17/17

16/5

 

1209/372

720/39

49/5

24/0

68/26

65/62

 

 

 

The study findings show that cannabis alone does not increase the likelihood of responsibility in an accident. However, most of the studies used a measurement of THC-COOH, an inactive metabolite that can remain in urine for several days. When the authors separated out THC alone, the risk ratio was slightly higher, even though it did not reach the required level of significance. In addition, as the concentration of THC increases, the more the ratio increases, once again suggesting a dose-response relationship. Furthermore, the cannabis and alcohol combination significantly increases risk. Without being able to draw any definite conclusions, there are some signs that their effects are in synergy and not merely additive.

Studies on injured drivers (Terhune (1982) and Hunter (1998)) have ratios somewhat higher than in the other studies on fatal accidents. According to Bates and Blakely (1999), the apparent reduction in the risk of a fatal accident stems from the fact that drivers under the influence of cannabis drive less dangerously, for example by reducing their speed.[5][23]

To conclude, we are rather in agreement with INSERM concerning these studies:

 

[translation] The findings definitely confirm the significant risk of alcohol, but generally fail to demonstrate that there is an effect of cannabis alone on the risk of being responsible for a fatal accident or an accident involving serious injury. The methodological difficulties that make such a demonstration difficult contribute considerably to the absence of statistically indisputable results. Analyses of responsibility nevertheless suggest that the association between alcohol and cannabis increases the risk of being responsible for an accident, compared to drinking alone; however, this finding needs to be consolidated. Lastly, the most recent data tend to show that there is a risk of becoming responsible at heavy concentrations of D9THC. This involves using cannabis immediately before driving, and perhaps applies also to chronic users. [6][24]

 

 

 

Detection and prevalence of cannabis in Europe and Quebec where no accidents are involved[7][12]

Reference country

 

Population

Detection method

Sample

Prevalence (%)

 
No presumption of driving under the influence of psychoactive substances

 

Germany, Kruger et al., 1995

 

Netherlands, Mathtijssen, 1998

 

Italy, Zancanner et al., 1995

 

Canada

Dussault et al., 2000

 

All drivers

 

 

Night drivers on weekends

 

Night drivers on weekends

 

Highway drivers (representative survey)

 

Screening: FPIA saliva

Confirmation: CG/SM saliva

Screening: combined saliva, perspiration and urine test

Clinical screening, clinical and toxicological check (blood, urine)

Urine

Saliva

Breathalyzer (alcohol)

 

2 234

(of 3 027)

 

293

(of 402)

 

1 237

 

 

2 281

2 260

5 281

 

0.6

 

 

5

 

 

1.5

 

 

5

(in progress)

> 0.8 : 0.8

 

With presumption of driving under the influence of psychoactive substances

 

Norway, Skurtveit et al., 1996

 

Denmark, Worm and Steentoft, 1996

 

United Kingdom, Scottland,  Seymour and

Oliver, 1999

 

Drivers

 

 

Drivers

 

 

Drivers

 

Screening: immunoassay blood;

Confirmation: CG/SM blood

Screening: RIA blood

Confirmation: CG/SM blood

Screening: immunoassay blood;

Confirmation: CG/SM blood

 

2 529

 

 

317

221

 

640

 

26

 

 

10

17

 

26

 

 

In all, it was observed that the detection rates for the presence of cannabis varied between 1% and 5% when there was no presumption of impaired driving. However, the missing data, which likely resulted from refusals to supply a sample, made it impossible to draw clear conclusions. The studies with presumption of driving under the influence of drugs had clearly higher results: between 10 and 26%. These results do not necessarily reveal a much higher prevalence of driving under the influence of psychoactive substances, but rather a higher level of vigilance by the police. Indeed, as we shall see immediately, the prevalence of cannabis detection in fatal accidents is no higher in Norway (7.5%) than in other countries.

 

Studies where an accident was involved

It is difficult to compare studies between countries because the detection methods, even in an accident context, varies widely from country to country. We wish to note once again that simply finding traces of cannabis in drivers involved in accidents is not necessarily a sign that its use was the cause of the accident. Nor does the absence of any screening result mean that no one was driving under the influence of cannabis.

The following table, adapted from INSERM results, refers to a number of recent studies in Europe, America and Australia.

 

Prevalence of impaired driving(ID) when there are accidents [8][13]

Country

 

Population

Detection method

Sample

Prevalence of cannabis (%)

Belgium

Meulemans et al., 1997

 

Spain

Alvarez et al., 1997

 

France, Mura et al., 2001

 

 

France, Kintz et al., 2000

 

 

Italy, Ferrara, 1990

 

 

Norway, Christophersen, 1995

 

United Kingdom, Tunbridge, 2000

 

Australia, Longo, 2000

 

Canada, Cimburra, 1990

 

United States, Logan, 1996

Casualty accidents (2-wheeled and cars)

 

 

Fatal accidents with suspected ID

 

Casualty accidents (control group: patients)

 

Casualty accidents

 

 

 

Injuries

Friday night checks

 

Injuries, non-fatal accidents

 

 

Fatal accidents (including 516 drivers)

 

Injuries (non-fatal accidents)

 

Killed