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|American Society for Action on Pain|
UI - 000136
AU - Cole L
AU - Hanning CD
TI - Review of the rectal use of opioids. [Review]
AB - The rectal route for the administration of opioid analgesics is often forgotten by physicians seeking
alternatives to the oral route. This article reviews the physiology of rectal drug absorption and such data as
exists on the different opioids that have been administered by this route. Conventional fatty-based
suppositories have a place in the management of chronic pain but the variability in dissolution and drug
absorption limit their usefulness. Recently, sustained release vehicles have become available that offer the
prospect of the attainment of steady analgesic drug concentrations with once or twice daily dosing. Early
studies with the morphine hydrogel suppository suggest that it may be capable of fulfilling this prospect.
Their inherent safety, as dose-dumping is impossible, will make them suitable for use in the home.
SO - Journal of Pain & Symptom Management 1990;5:118-12