The National Commission on Marihuana and Drug Abuse

Marihuana - A Signal of Misunderstanding.

Chapter II

marihuana use and its effects

Reverse Tolerance

Repeated exposure to marihuana has been said to cause an individual to need lesser amounts of the drug to achieve the same degree of intoxication. This "reverse tolerance" may be related to one's learning to get high or to the recognition of the subtle intoxication at low doses. Or perhaps, such tolerance reflects an increase in the body's ability to change the drug to an active chemical. To date, the existence of "reverse tolerance" has not been substantiated in an experimental setting.