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American Society for Action on Pain

UI - 000039

AU - Carmody J

AU - Cooper K

TI - Swim stress reduces chronic pain in mice through an opioid mechanism

AB - Chronic nociception has been studied in male mice by means of the formalin test in which forelimb

motor behaviour is scored after subcutaneous formalin injection. The rating remained above 2.0 for 30 min

after the injection (scale range 0-3). The magnitude of the nociception has been compared with that reported

in other animal types. Mice are more sensitive than rats, cats and monkeys. The stress of a swim of 3 min has

been found to reduce nociception by up to 25%. This analgesia is wholly opioid in nature, being abolished by

a moderate dose of naloxone (1 mg/kg)

SO - Neuroscience Letters 1987;74:358-363