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American Society for Action on Pain

UI - 000065

AU - Drexel H

AU - Lang AH

AU - Spiegel RW

AU - Abbrederis K

TI - Pump-guided continuous subcutaneous opiate infusion for the treatment of the most severe pain.


AB - The continuous subcutaneous infusion of opiate, a new approach to the alleviation of severe chronic

pain, has been carried out using a pump system normally employed for the infusion of insulin. Relapses of

pain can be controlled with bolus doses. This mode of application was compared with conventional therapy

in 11 patients. All patients were free of pain during the continuous infusion, but none showed a satisfactory

response during conventional treatment. The improved response under continuous opiate infusion was

attained with much lower doses and thus with fewer side effects. The procedure is therefore highly effective

and well tolerated

SO - Deutsche Medizinische Wochenschrift 1985;110:1063-1067